Mix and match backbones for the formation of H-bonded duplexes† †Electronic supplementary information (ESI) available: Detailed experimental procedures with spectroscopic characterization data, 31P NMR titration spectra and binding isotherms. See DOI: 10.1039/c5sc04467g Click here for additional data file.

نویسندگان

  • Giulia Iadevaia
  • Alexander E. Stross
  • Anja Neumann
  • Christopher A. Hunter
چکیده

To 80 ml 37% aqueous formaldehyde and 80 ml concentrated HCl solution, di-tertbutyl(chloro)phosphane (8.2 ml, 43.0 mol) was added and the mixture was heated to 100 ̊C and stirred overnight. The solution was allowed to cool, then neutralized with NaOH (14 g) and NaHCO3 (7.0 g), extracted with CHCl3 (200 x 3 ml), washed with brine (100 ml), dried with Na2SO4 and the solvent was removed under reduced pressure. The crude was then purified by recrystallization with hexane at 69 ̊C. The product was isolated as a white solid (5.4 g, 65%).

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Homochiral oligomers with highly flexible backbones form stable H-bonded duplexes† †Electronic supplementary information (ESI) available: Detailed experimental procedures and 1H, 13C and 31P NMR spectra of all compounds, NMR titration spectra, thermal denaturation spectra and molecular modelling methods. See DOI: 10.1039/c6sc02995g Click here for additional data file.

Two homochiral building blocks featuring a protected thiol, an alkene and a H-bond recognition unit (phenol or phosphine oxide) have been prepared. Iterative photochemical thiol–ene coupling reactions were used to synthesize oligomers containing 1-4 phosphine oxide and 1-4 phenol recognition sites. Length-complementary H-bond donor and H-bond acceptor oligomers were found to form stable duplexe...

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Biphen[n]arenes† †Electronic supplementary information (ESI) available: Detailed synthetic procedures and characterization, crystal data for EtBP3 and EtBP4, ESI spectra, additional 1H NMR spectra, Job plots, and determination of the association constants. CCDC 1016929 and 1016930. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02422b Click here for additional data file. Click here for additional data file.

Department of Chemistry, Shanghai Univ E-mail: [email protected] Shanghai Key Laboratory of Magnetic Reson Normal University, Shanghai, 200062, P. R. Beijing National Laboratory for Molecular China † Electronic supplementary information procedures and characterization, crystal additional H NMR spectra, Job plots, constants. CCDC 1016929 and 1016930. CIF or other electronic format see DOI: 10 ‡ Th...

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عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2016