Mix and match backbones for the formation of H-bonded duplexes† †Electronic supplementary information (ESI) available: Detailed experimental procedures with spectroscopic characterization data, 31P NMR titration spectra and binding isotherms. See DOI: 10.1039/c5sc04467g Click here for additional data file.
نویسندگان
چکیده
To 80 ml 37% aqueous formaldehyde and 80 ml concentrated HCl solution, di-tertbutyl(chloro)phosphane (8.2 ml, 43.0 mol) was added and the mixture was heated to 100 ̊C and stirred overnight. The solution was allowed to cool, then neutralized with NaOH (14 g) and NaHCO3 (7.0 g), extracted with CHCl3 (200 x 3 ml), washed with brine (100 ml), dried with Na2SO4 and the solvent was removed under reduced pressure. The crude was then purified by recrystallization with hexane at 69 ̊C. The product was isolated as a white solid (5.4 g, 65%).
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